Preventing Oxidative Stress in the Liver: An Opportunity for GLP-1 and/or PASK.

ABSTRACT: The liver's high metabolic activity and detoxification functions generate reactive oxygen species, mainly through oxidative phosphorylation in the mitochondria of hepatocytes. In contrast, it also has a potent antioxidant mechanism for counterbalancing the oxidant's effect and relieving oxidative stress. PAS kinase (PASK) is a serine/threonine kinase containing an N-terminal Per-Arnt-Sim (PAS) domain, able to detect redox state. During fasting/feeding changes, PASK regulates the expression and activation of critical liver proteins involved in carbohydrate and lipid metabolism and mitochondrial biogenesis. Interestingly, the functional inactivation of PASK prevents the development of a high-fat diet (HFD)-induced obesity and diabetes. In addition, PASK deficiency alters the activity of othe

SUBMITTER: Hurtado-Carneiro V 

PROVIDER: S-EPMC8698360 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature