Cellular Senescence: Mechanisms and Therapeutic Potential.

ABSTRACT: Cellular senescence is a complex and multistep biological process which cells can undergo in response to different stresses. Referring to a highly stable cell cycle arrest, cellular senescence can influence a multitude of biological processes-both physiologically and pathologically. While phenotypically diverse, characteristics of senescence include the expression of the senescence-associated secretory phenotype, cell cycle arrest factors, senescence-associated β-galactosidase, morphogenesis, and chromatin remodelling. Persistent senescence is associated with pathologies such as aging, while transient senescence is associated with beneficial programmes, such as limb patterning. With these implications, senescence-based translational studies, namely senotherapy and pro-senescence therapy, a

SUBMITTER: Liao Z 

PROVIDER: S-EPMC8698401 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature