Reintroduction of DJ-1 in Muller Cells Inhibits Retinal Degeneration in the DJ-1 Deficient Retina.

ABSTRACT: The eye is continuously under oxidative stress due to high metabolic activity and reactive oxygen species generated by daily light exposure. The redox-sensitive protein DJ-1 has proven to be essential in order to protect retina and retinal pigment epithelium (RPE) from oxidative-stress-induced degeneration. Here, we analyzed the specific role of Müller cell DJ-1 in the adult zebrafish retina by re-establishing Müller-cell-specific DJ-1 expression in a DJ-1 knockout retina. Loss of DJ-1 resulted in an age-dependent retinal degeneration, including loss of cells in the ganglion cell layer, retinal thinning, photoreceptor disorganization and RPE cell dysfunction. The degenerative phenotype induced by the absence of DJ-1 was inhibited by solely expressing DJ-1 in Müller cells. The protective ef

SUBMITTER: Gharbi N 

PROVIDER: S-EPMC8698414 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature