Ontology highlight
ABSTRACT:
SUBMITTER: Blockhuys S
PROVIDER: S-EPMC8698757 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Blockhuys Stéphanie S Hildesjö Camilla C Olsson Hans H Vahdat Linda L Wittung-Stafshede Pernilla P
Biomedicines 20211212 12
Copper plays a key role in cancer metastasis, which is the most common cause of cancer death. Copper depletion treatment with tetrathiomolybdate (TM) improved disease-free survival in breast cancer patients with high risk of recurrence in a phase II clinical trial. Because the copper metallochaperone ATOX1 was recently reported to drive breast cancer cell migration and breast cancer migration is a critical factor in metastasis, we tested if ATOX1 expression levels in primary tumor tissue could p ...[more]