Integration and Spatial Organization of Signaling by G Protein-Coupled Receptor Homo- and Heterodimers.

ABSTRACT: Information flow from a source to a receiver becomes informative when the recipient can process the signal into a meaningful form. Information exchange and interpretation is essential in biology and understanding how cells integrate signals from a variety of information-coding molecules into complex orchestrated responses is a major challenge for modern cell biology. In complex organisms, cell to cell communication occurs mostly through neurotransmitters and hormones, and receptors are responsible for signal recognition at the membrane level and information transduction inside the cell. The G protein-coupled receptors (GPCRs) are the largest family of membrane receptors, with nearly 800 genes coding for these proteins. The recognition that GPCRs may physically interact with each other has

SUBMITTER: Maggio R 

PROVIDER: S-EPMC8698773 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature