Inflammatory, Oxidative Stress, and Apoptosis Effects in Zebrafish Larvae after Rapid Exposure to a Commercial Glyphosate Formulation.

ABSTRACT: Glyphosate-based herbicides (GBH) are the most used herbicides in the world, carrying potentially adverse consequences to the environment and non-target species due to their massive and inadequate use. This study aimed to evaluate the effects of acute exposure to a commercial formulation of glyphosate, Roundup® Flex (RF), at environmentally relevant and higher concentrations in zebrafish larvae through the assessment of the inflammatory, oxidative stress and cell death response. Transgenic Tg(mpxGFP)i114 and wild-type (WT) zebrafish larvae (72 h post-fertilisation) were exposed to 1, 5, and 10 µg mL-1 of RF (based on the active ingredient concentration) for 4 h 30 min. A concentration of 2.5 µg mL-1 CuSO4 was used as a positive control. Copper sulphate exposure showed effectiveness in enha

SUBMITTER: Lanzarin G 

PROVIDER: S-EPMC8698920 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature