Relevance of Dynamic ¹⁸F-DOPA PET Radiomics for Differentiation of High-Grade Glioma Progression from Treatment-Related Changes.

ABSTRACT: This study evaluates the relevance of ¹⁸F-DOPA PET static and dynamic radiomics for differentiation of high-grade glioma (HGG) progression from treatment-related changes (TRC) by comparing diagnostic performances to the current PET imaging standard of care. Eighty-five patients with histologically confirmed HGG and investigated by dynamic ¹⁸F-FDOPA PET in two institutions were retrospectively selected. ElasticNet logistic regression, Random Forest and XGBoost machine models were trained with different sets of features-radiomics extracted from static tumor-to-background-ratio (TBR) parametric images, radiomics extracted from time-to-peak (TTP) parametric images, as well as combination of both-in order to discriminate glioma progression from TRC at 6 months from the PET

SUBMITTER: Ahrari S 

PROVIDER: S-EPMC8698938 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature