Kidney Cancer and Chronic Kidney Disease: Too Close for Comfort.
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ABSTRACT:
SUBMITTER: Pinto PC
PROVIDER: S-EPMC8699019 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Kidney Cancer and Chronic Kidney Disease: Too Close for Comfort.
Pinto Pedro Caetano PC Rönnau Cindy C Burchardt Martin M Wolff Ingmar I
Biomedicines 20211124 12
Kidney cancer and chronic kidney disease are two renal pathologies with very different clinical management strategies and therapeutical options. Nonetheless, the cellular and molecular mechanisms underlying both conditions are closely related. Renal physiology is adapted to operate with a limited oxygen supply, making the kidney remarkably equipped to respond to hypoxia. This tightly regulated response mechanism is at the heart of kidney cancer, leading to the onset of malignant cellular phenoty ...[more]
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