Nucleolar Stress Functions Upstream to Stimulate Expression of Autophagy Regulators.

ABSTRACT: Ribosome biogenesis is essential for protein synthesis, cell growth and survival. The process takes places in nucleoli and is orchestrated by various proteins, among them RNA polymerases I-III as well as ribosome biogenesis factors. Perturbation of ribosome biogenesis activates the nucleolar stress response, which classically triggers cell cycle arrest and apoptosis. Nucleolar stress is utilized in modern anti-cancer therapies, however, also contributes to the development of various pathologies, including cancer. Growing evidence suggests that nucleolar stress stimulates compensatory cascades, for instance bulk autophagy. However, underlying mechanisms are poorly understood. Here we demonstrate that induction of nucleolar stress activates expression of key autophagic regulators such as ATG

SUBMITTER: Dannheisig DP 

PROVIDER: S-EPMC8699128 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature