Bile Acid Dysregulation Is Intrinsically Related to Cachexia in Tumor-Bearing Mice.

ABSTRACT: Bile acids exert diverse actions on host metabolism and immunity through bile acid-activated receptors, including Takeda G protein-coupled receptor 5 (TGR5). We have recently evidenced an alteration in bile acids in cancer cachexia, an inflammatory and metabolic syndrome contributing to cancer death. This current study aims to further explore the links emerging between bile acids and cancer cachexia. First, we showed that bile flow is reduced in cachectic mice. Next, comparing mice inoculated with cachexia-inducing and with non-cachexia-inducing C26 colon carcinoma cells, we demonstrated that alterations in the bile acid pathways and profile are directly associated with cachexia. Finally, we performed an interventional study using ursodeoxycholic acid (UDCA), a compound commonly used in he

SUBMITTER: Thibaut MM 

PROVIDER: S-EPMC8699129 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature