Pediatric versus Adult Medulloblastoma: Towards a Definition That Goes beyond Age.

ABSTRACT: Medulloblastoma is a rare malignant brain tumor that predominantly affects children but also occurs in adults. The incidence declines significantly after age 15, and distinct tumor molecular features are seen across the age spectrum. Standard of care treatment consists of maximal safe surgical resection followed by adjuvant radiation and/or chemotherapy. Adjuvant treatment decisions are based on individual patient risk factors and have been informed by decades of prospective clinical trials. These trials have historically relied on arbitrary age cutoffs for inclusion (age 16, 18, or 21, for example), while trials that include adult patients or stratify patients by molecular features of disease have been rare. The aim of this literature review is to review the history of clinical trials in

SUBMITTER: Wooley JR 

PROVIDER: S-EPMC8699201 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature