Deficiency of Cathelicidin Attenuates High-Fat Diet Plus Alcohol-Induced Liver Injury through FGF21/Adiponectin Regulation.

ABSTRACT: Alcohol consumption and obesity are known risk factors of steatohepatitis. Here, we report that the deficiency of CRAMP (cathelicidin-related antimicrobial peptide-gene name: Camp) is protective against a high-fat diet (HFD) plus acute alcohol (HFDE)-induced liver injury. HFDE markedly induced liver injury and steatosis in WT mice, which were attenuated in Camp^-/- mice. Neutrophil infiltration was lessened in the liver of Camp^-/- mice. HFDE feeding dramatically increased epididymal white adipose tissue (eWAT) mass and induced adipocyte hypertrophy in WT mice, whereas these effects were attenuated by the deletion of Camp. Furthermore, Camp^-/- mice had significantly increased eWAT lipolysis, evidenced by up-regulated express

SUBMITTER: Li F 

PROVIDER: S-EPMC8699208 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature