Interplay between Genome, Metabolome and Microbiome in Colorectal Cancer.

ABSTRACT:

Background

Colorectal cancer (CRC), a major health concern, is developed depending on environmental, genetic and microbial factors. The microbiome and metabolome have been analyzed to study their role in CRC. However, the interplay of host genetics with those layers in CRC remains unclear.

Methods

120 individuals were sequenced and association analyses were carried out for adenoma and CRC risk, and for selected components of the microbiome and metabolome. The epistasis between genes located in cholesterol pathways was analyzed; modifiable risk factors were studied using Mendelian randomization; and the three omic layers were used to integrate their data and to build risk prediction models.

Results

We detected genetic variants that were associated to components of meta

SUBMITTER: Garcia-Etxebarria K 

PROVIDER: S-EPMC8699218 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature