Identification of Genetic Variants Associated with Sex-Specific Lung-Cancer Risk.

ABSTRACT:

Background

The incidence of lung cancer differs between men and women, suggesting the potential role of sex-specific influences in susceptibility to this cancer. While behavioural differences may account for some of the risk, another possibility is that X chromosome susceptibility genes may have an effect. Little is known about genetic variants on the X chromosome that contribute to sex-specific lung-cancer risk, so we investigated this in a previously characterized cohort.

Methods

We conducted a genetic association reanalysis of 518 lung cancer patients and 844 controls to test for lung cancer susceptibility variants on the X chromosome. Annotated gene expression, co-expression analysis, pathway, and immune infiltration analyses were also performed.

Results

24 SNPs w

SUBMITTER: Shi X 

PROVIDER: S-EPMC8699314 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature