Can Any Drug Be Repurposed for Cancer Treatment? A Systematic Assessment of the Scientific Literature.

ABSTRACT: Drug repurposing is a complementary pathway for introducing new drugs against cancer. Broad systematic assessments of ongoing repurposing efforts in oncology are lacking, but may be helpful to critically appraise current and future efforts. Hence, we conducted a systematic PubMed search encompassing 100 frequently prescribed and 100 randomly selected drugs, and assessed the published preclinical anti-cancer effects. Furthermore, we evaluated all the identified original articles for methodological quality. We found reports indicating anti-cancer effects for 138/200 drugs, especially among frequently prescribed drugs (81/100). Most were reports suggesting single-agent activity of the drugs (61%). Basic information, such as the cell line used or control treatments utilized, were reported cons

SUBMITTER: Stransky N 

PROVIDER: S-EPMC8699650 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature