Clinical Outcomes after International Referral of Uveal Melanoma Patients for Proton Therapy.

ABSTRACT: To assess oncological and ophthalmological outcomes after international referral of uveal melanoma patients for proton therapy. This is a retrospective study among Dutch uveal melanoma patients who were treated in Switzerland with 60.0 CGE proton therapy (in 4 fractions) from 1987 to 2019. All patients were ineligible for brachytherapy due to tumour size and/or proximity to the optic nerve. Time-to-event analyses were performed using Kaplan-Meier's methodology and Cox proportional hazards models. There were 103 patients (104 eyes) with a median largest tumour diameter of 19 mm (range 6-26 mm). Tumours were localised centrally (11%), mid-peripherally (65%) or peripherally (34%). Median follow-up was 7 years. Five-year local control, distant metastasis-free survival and eye preservation rate

SUBMITTER: Marinkovic M 

PROVIDER: S-EPMC8699723 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature