Cerebrolysin Prevents Brain Injury in a Mouse Model of Liver Damage.

ABSTRACT: Liver damage can lead to secondary organ damage by toxic substances and catabolic products accumulation which can increase the permeability of blood-brain barrier, leading to cognitive impairment. The only real treatment for end stage liver failure is grafting. With some, but not all, neurological symptoms subsiding after transplantation, the presence of brain damage can impair both the short and long-term outcome. We tested if Cerebrolysin can prevent brain injury in an experimental model of non-viral liver damage in mice. Behavior, abdominal ultrasound evaluation and immunohistochemistry were used to evaluate the animals. No ultrasound or behavior differences were found between the control and treated animals, with both groups displaying more anxiety and no short-term memory benefit comp

SUBMITTER: Morega S 

PROVIDER: S-EPMC8699728 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature