The Effects of Physical Activity on Cancer Patients Undergoing Treatment with Immune Checkpoint Inhibitors: A Scoping Review.

ABSTRACT: Cancer therapies are associated with multiple adverse effects, including (but not limited to) cancer-related fatigue (CRF). Fatigue is one of the most common side effects of immune checkpoint inhibitors (ICIs), occurring in up to 25% of patients. Physical activity has been shown to help reduce CRF through modulating the immune system, and may synergistically aid in the anti-tumor effects of ICIs. This review describes the nature and scope of evidence for the effects associated with concurrent physical activity while undergoing ICI therapy. Scoping review methodology was utilized to identify studies, extract data, and collate and summarize results. In literature published from January 2010 through to August 2021, only one human study and three pre-clinical studies met inclusion criteria. Ex

SUBMITTER: Shaver AL 

PROVIDER: S-EPMC8699800 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature