DNA Environment of Centromeres and Non-Homologous Chromosomes Interactions in Mouse.

ABSTRACT: Although the pericentromeric regions of chromosomes that are enriched in tandemly repeated satellite DNA represent a significant part of eukaryotic genomes, they remain understudied, which is mainly due to interdisciplinary knowledge gaps. Recent studies suggest their important role in genome regulation, karyotype stability, and evolution. Thus, the idea of satellite DNA as a junk part of the genome has been refuted. The integration of data regarding molecular composition, chromosome behaviour, and the details of the in situ organization of pericentromeric regions is of great interest. The objective of this work was a cytogenetic analysis of the interactions between pericentromeric regions from non-homologous chromosomes in mouse spermatocytes using immuno-FISH. We analysed two events: the

SUBMITTER: Spangenberg V 

PROVIDER: S-EPMC8699862 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature