Emerging Molecular Dependencies of Mutant EGFR-Driven Non-Small Cell Lung Cancer.

ABSTRACT: Epidermal growth factor receptor (EGFR) mutations are the molecular driver of a subset of non-small cell lung cancers (NSCLC); tumors that harbor these mutations are often dependent on sustained oncogene signaling for survival, a concept known as "oncogene addiction". Inhibiting EGFR with tyrosine kinase inhibitors has improved clinical outcomes for patients; however, successive generations of inhibitors have failed to prevent the eventual emergence of resistance to targeted agents. Although these tumors have a well-established dependency on EGFR signaling, there remain questions about the underlying genetic mechanisms necessary for EGFR-driven oncogenesis and the factors that allow tumor cells to escape EGFR dependence. In this review, we highlight the latest findings on mutant EGFR depen

SUBMITTER: Farnsworth DA 

PROVIDER: S-EPMC8699920 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature