Whole embryonic detection of maternal microchimeric cells highlights significant differences in their numbers among individuals.

ABSTRACT: During pregnancy in placental mammals, small numbers of maternal cells (maternal microchimeric cells, or MMc cells) migrate into the fetus and persist decades, or perhaps for the rest of their lives, and higher frequencies of MMc cells are reported to correlate with variety of phenomena, such as immune tolerance, tissue repair, and autoimmune diseases. While detection of these MMc cells is considered in all pregnancies, their frequency differs largely according to tissue type and disease cases, and it remains unclear whether the number of MMc cells differs significantly among embryos in normal pregnancies. Here, for the first time, we developed a whole embryonic detection method for MMc cells using transgenic mice and counted live MMc cells in each individual embryo. Using this technique,

SUBMITTER: Fujimoto K 

PROVIDER: S-EPMC8699925 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature