Platelet Activation Mechanisms and Consequences of Immune Thrombocytopenia.

ABSTRACT: Autoimmune disorders are often associated with low platelet count or thrombocytopenia. In immune-induced thrombocytopenia (IIT), a common mechanism is increased platelet activity, which can have an increased risk of thrombosis. In addition, or alternatively, auto-antibodies suppress platelet formation or augment platelet clearance. Effects of the auto-antibodies are linked to the unique structural and functional characteristics of platelets. Conversely, prior platelet activation may contribute to the innate and adaptive immune responses. Extensive interplay between platelets, coagulation and complement activation processes may aggravate the pathology. Here, we present an overview of the reported molecular causes and consequences of IIT in the most common forms of autoimmune disorders. Thes

SUBMITTER: Sun S 

PROVIDER: S-EPMC8699996 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature