Poincare Maps and Aperiodic Oscillations in Leukemic Cell Proliferation Reveal Chaotic Dynamics.

ABSTRACT: Biological systems are dynamic systems featuring two very common characteristics; Initial conditions and progression over time. Conceptualizing this on tumour models it can lead to important conclusions about disease progression, as well as the disease's "starting point". In the present study we tried to answer two questions: (a) which are the evolving properties of proliferating tumour cells that started from different initial conditions and (b) we have attempted to prove that cell proliferation follows chaotic orbits and it can be described by the use of Poincaré maps. As a model we have used the acute lymphoblastic leukemia cell line CCRF-CEM. Measurements of cell population were taken at certain time points every 24 h or 48 h. In addition to the population measurements flow cytometry s

SUBMITTER: Adamopoulos K 

PROVIDER: S-EPMC8700028 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature