RETRACTED: Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A₁ Receptor Ligands.

ABSTRACT: Adenosine A₁ receptor (A₁R) activation, stimulating lipogenesis and decreasing insulin resistance, could be useful for metabolic syndrome management in obese subjects. Since full A₁R agonists induce harmful side-effects, while partial agonists show a better pharmacological profile, we investigated the influence of two derivatives of the full A₁R agonist 2-chloro-N⁶-cyclopentyladenosine (CCPA), C1 and C2 behaving as A₁R partial agonists in animal models, on the adipogenic differentiation of stromal/stem cells (ASCs) from human subcutaneous adipose tissue, which mainly contribute to increase fat mass in obesity. The ASCs from normal-weight subjects showed increased proliferation and A₁R expression but reduced

SUBMITTER: Zuccarini M 

PROVIDER: S-EPMC8700077 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature