The Role of Farnesoid X Receptor in Accelerated Liver Regeneration in Rats Subjected to ALPPS.

ABSTRACT:

Background

the role of bile acid (BA)-induced farnesoid X receptor (Fxr) signaling in liver regeneration following associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) was investigated in a rat model.

Methods

Male Wistar rats underwent portal vein ligation (PVL) (n = 30) or ALPPS (n = 30). Animals were sacrificed pre-operatively and at 24, 48, 72, or 168 h after intervention. Regeneration rate, Ki67 index, hemodynamic changes in the hepatic circulation, and BA levels were assessed. Transcriptome analysis of molecular regulators involved in the Fxr signaling pathway, BA transport, and BA production was performed.

Results

ALLPS induced more extensive liver regeneration (p < 0.001) and elevation of systemic and portal B

SUBMITTER: Daradics N 

PROVIDER: S-EPMC8700148 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature