Estimating Glomerular Filtration Rate from Serum Myo-Inositol, Valine, Creatinine and Cystatin C.

ABSTRACT: Assessment of renal function relies on the estimation of the glomerular filtration rate (eGFR). Existing eGFR equations, usually based on serum levels of creatinine and/or cystatin C, are not uniformly accurate across patient populations. In the present study, we expanded a recent proof-of-concept approach to optimize an eGFR equation targeting the adult population with and without chronic kidney disease (CKD), based on a nuclear magnetic resonance spectroscopy (NMR) derived 'metabolite constellation' (GFR_NMR). A total of 1855 serum samples were partitioned into development, internal validation and external validation datasets. The new GFR_NMR equation used serum myo-inositol, valine, creatinine and cystatin C plus age and sex. GFR_NMR had a lower bias to tra

SUBMITTER: Stammler F 

PROVIDER: S-EPMC8700166 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature