Potential Combination Drug Therapy to Prevent Redox Stress and Mitophagy Dysregulation in Retinal Muller Cells under High Glucose Conditions: Implications for Diabetic Retinopathy.

ABSTRACT: Chronic hyperglycemia-induced thioredoxin-interacting protein (TXNIP) expression, associated oxidative/nitrosative stress (ROS/RNS), and mitochondrial dysfunction play critical roles in the etiology of diabetic retinopathy (DR). However, there is no effective drug treatment to prevent or slow down the progression of DR. The purpose of this study is to examine if a combination drug treatment targeting TXNIP and the mitochondria-lysosome pathway prevents high glucose-induced mitochondrial stress and mitophagic flux in retinal Müller glial cells in culture, relevant to DR. We show that diabetes induces TXNIP expression, redox stress, and Müller glia activation (gliosis) in rat retinas when compared to non-diabetic rat retinas. Furthermore, high glucose (HG, 25 mM versus low glucose, LG 5.5 mM

SUBMITTER: Singh LP 

PROVIDER: S-EPMC8700204 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature