Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells.

ABSTRACT: Physiological and pathological morphogenetic events involve a wide array of collective movements, suggesting that multicellular arrangements confer biochemical and biomechanical properties contributing to tissue-scale organization. The Ciona cardiopharyngeal progenitors provide the simplest model of collective cell migration, with cohesive bilateral cell pairs polarized along the leader-trailer migration path while moving between the ventral epidermis and trunk endoderm. We use the Cellular Potts Model to computationally probe the distributions of forces consistent with shapes and collective polarity of migrating cell pairs. Combining computational modeling, confocal microscopy, and molecular perturbations, we identify cardiopharyngeal progenitors as the simplest cell collective maintainin

SUBMITTER: Bernadskaya YY 

PROVIDER: S-EPMC8700272 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature