Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure.

ABSTRACT: Pneumolysin (PLY) is a pore-forming toxin of Streptococcus pneumoniae that contributes substantially to the inflammatory processes underlying pneumococcal pneumonia and lung injury. Host responses against S. pneumoniae are regulated in part by neutrophils and platelets, both individually and in cooperative interaction. Previous studies have shown that PLY can target both neutrophils and platelets, however, the mechanisms by which PLY directly affects these cells and alters their interactions are not completely understood. In this study, we characterize the effects of PLY on neutrophils and platelets and explore the mechanisms by which PLY may induce neutrophil-platelet interactions. In vitro studies demonstrated that PLY causes the formation of neutrophil extracellular traps (NETs) and the

SUBMITTER: Letsiou E 

PROVIDER: S-EPMC8700313 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature