Blood Pumps for Extracorporeal Membrane Oxygenation: Platelet Activation During Different Operating Conditions.

ABSTRACT: Extracorporeal membrane oxygenation (ECMO) is a therapy used in severe cardiopulmonary failure. Blood is pumped through an artificial circuit exposing it to nonphysiologic conditions, which promote platelet activation and coagulation. Centrifugal pumps used at lower flow rates than their design point may lose pump efficiency and increase the risk of hemolysis. In this study, thrombogenic properties of two ECMO pumps designed for adult and neonatal use were evaluated using simulations in different flow scenarios. Three scenarios, adult pump in adult mode (4 L/min), adult pump in baby mode (300 ml/min), and neonatal pump used in its design point (300 ml/min), were simulated using computational fluid dynamics. The flow was numerically seeded with platelets, whose activation state was computed

SUBMITTER: Fiusco F 

PROVIDER: S-EPMC8700320 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature