NAPRT Expression Regulation Mechanisms: Novel Functions Predicted by a Bioinformatics Approach.

ABSTRACT: The nicotinate phosphoribosyltransferase (NAPRT) gene has gained relevance in the research of cancer therapeutic strategies due to its main role as a NAD biosynthetic enzyme. NAD metabolism is an attractive target for the development of anti-cancer therapies, given the high energy requirements of proliferating cancer cells and NAD-dependent signaling. A few studies have shown that NAPRT expression varies in different cancer types, making it imperative to assess NAPRT expression and functionality status prior to the application of therapeutic strategies targeting NAD. In addition, the recent finding of NAPRT extracellular form (eNAPRT) suggested the involvement of NAPRT in inflammation and signaling. However, the mechanisms regulating NAPRT gene expression have never been thoroughly address

SUBMITTER: Duarte-Pereira S 

PROVIDER: S-EPMC8700865 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature