A Detailed Gene Expression Map of Giardia Encystation.

ABSTRACT: Giardia intestinalis is an intestinal protozoan parasite that causes diarrheal infections worldwide. A key process to sustain its chain of transmission is the formation of infectious cysts in the encystation process. We combined deep RNAseq of a broad range of encystation timepoints to produce a high-resolution gene expression map of Giardia encystation. This detailed transcriptomic map of encystation confirmed a gradual change of gene expression along the time course of encystation, showing the most significant gene expression changes during late encystation. Few genes are differentially expressed early in encystation, but the major cyst wall proteins CWP-1 and -2 are highly up-regulated already after 3.5 h encystation. Several transcription factors are sequentially up-regul

SUBMITTER: Rojas-Lopez L 

PROVIDER: S-EPMC8700996 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature