Longitudinal Transcriptional Analysis of Peripheral Blood Leukocytes in COVID Convalescent Donors

ABSTRACT: Abstract Introduction Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) can induce a strong host immune response. Several groups have investigated the course of antibody responses in patients recovering from SARS-CoV-2 infections but little is known about the recovery of cellular immunity. This study investigated the cellular immune response in people who had recovered from SARS-CoV2 infection. Methods 162 coronavirus disease 2019 (COVID-19) convalescent plasma donors (CCD) and 40 healthy donor (HD) controls were enrolled prospectively in an IRB-approved protocol (Clinical Trials Number: NCT04360278) and provided written informed consent to participate in the study. Using the nCounter platform and host response panel with 785 genes across more than 50 pathways, we compared transc

SUBMITTER: Gedda M 

PROVIDER: S-EPMC8701674 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature