Genetic Insights into the Impact of Complement in Alzheimer's Disease.

ABSTRACT: The presence of complement activation products at sites of pathology in post-mortem Alzheimer's disease (AD) brains is well known. Recent evidence from genome-wide association studies (GWAS), combined with the demonstration that complement activation is pivotal in synapse loss in AD, strongly implicates complement in disease aetiology. Genetic variations in complement genes are widespread. While most variants individually have only minor effects on complement homeostasis, the combined effects of variants in multiple complement genes, referred to as the "complotype", can have major effects. In some diseases, the complotype highlights specific parts of the complement pathway involved in disease, thereby pointing towards a mechanism; however, this is not the case with AD. Here we review the c

SUBMITTER: Torvell M 

PROVIDER: S-EPMC8702080 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature