Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking.

ABSTRACT:

Background

The traditional Chinese medicine prescription Suhexiang Pill (SHXP), a classic prescription for the treatment of plague, has been recommended in the 2019 Guideline for coronavirus disease 2019 (COVID-19) diagnosis and treatment of a severe type of COVID-19. However, the bioactive compounds and underlying mechanisms of SHXP for COVID-19 prevention and treatment have not yet been elucidated. This study investigates the mechanisms of SHXP in the treatment of COVID-19 based on network pharmacology and molecular docking.

Methods

First, the bioactive ingredients and corresponding target genes of the SHXP were screened from the traditional Chinese medicine systems pharmacology database and analysis platform database. Then, we compiled COVID-19 disease targets from the Ge

SUBMITTER: Li J 

PROVIDER: S-EPMC8702253 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature