Recurrent nocardiosis in solid organ transplant recipients: An evaluation of secondary prophylaxis.

ABSTRACT:

Background

Immunocompromised individuals are at risk for Nocardia infection, with a recurrence rate of approximately 5%. Solid organ transplant (SOT) recipients often receive secondary prophylaxis due to their requirement of lifelong immunosuppression. However, data supporting this practice is sparse. We sought to evaluate Nocardia recurrence in SOT recipients, specifically evaluating secondary prophylaxis.

Methods

We conducted a retrospective cohort study of SOT recipients diagnosed with nocardiosis from 2000 through 2020. We included adult SOT recipients who completed their course of Nocardia therapy and had at least 6 months of posttherapy follow-up. The primary outcome was Nocardia recurrence, which included relapse and reinfection.

Results

One hundred two patient

SUBMITTER: Yetmar ZA 

PROVIDER: S-EPMC8702471 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature