Demographic correlates of inflammatory and antiviral gene expression in the study of Midlife in the United States (MIDUS).

ABSTRACT: The present study examined the demographic correlates of gene expression in a sample of adults (n = 543) from the Study of Midlife in the United States (MIDUS). Inflammatory and antiviral gene sets were operationalized using a priori composite scores and empirically derived co-regulatory gene sets. For both composite scores and co-regulatory gene sets, White/European Americans showed lower while Black/African Americans showed higher expression of genes involved in interferon responses and antibody synthesis. The effects of chronological age on gene expression varied by sex, such that pro-inflammatory gene expression increased with age more rapidly for females than males. The difference between the average expression of inflammatory and antiviral genes also increased with age

SUBMITTER: Mann FD 

PROVIDER: S-EPMC8702472 | biostudies-literature | 2020 Jul-Sep

REPOSITORIES: biostudies-literature