Hematopoietic Cell-Specific SLC37A2 Deficiency Accelerates Atherosclerosis in LDL Receptor-Deficient Mice.

ABSTRACT: Macrophages play a central role in the pathogenesis of atherosclerosis. Our previous study demonstrated that solute carrier family 37 member 2 (SLC37A2), an endoplasmic reticulum-anchored phosphate-linked glucose-6-phosphate transporter, negatively regulates macrophage Toll-like receptor activation by fine-tuning glycolytic reprogramming in vitro. Whether macrophage SLC37A2 impacts in vivo macrophage inflammation and atherosclerosis under hyperlipidemic conditions is unknown. We generated hematopoietic cell-specific SLC37A2 knockout and control mice in C57Bl/6 Ldlr^-/- background by bone marrow transplantation. Hematopoietic cell-specific SLC37A2 deletion in Ldlr^-/- mice increased plasma lipid concentrations after 12-16 wks of Western diet induction, atte

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC8702732 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature