Oral and Gut Microbial Carbohydrate-Active Enzymes Landscape in Health and Disease.

ABSTRACT: Inter-individual variability in the microbial gene complement encoding for carbohydrate-active enzymes (CAZymes) can profoundly regulate how the host interacts with diverse carbohydrate sources thereby influencing host health. CAZy-typing, characterizing the microbiota-associated CAZyme-coding genes within a host individual, can be a useful tool to predict carbohydrate pools that the host can metabolize, or identify which CAZyme families are underrepresented requiring supplementation via microbiota transplantation or probiotics. CAZy-typing, moreover, provides a novel framework to search for disease biomarkers. As a proof of concept, we used publicly available metagenomes (935) representing 310 type strain bacterial genomes to establish the link between disease status and CAZymes in the or

SUBMITTER: Onyango SO 

PROVIDER: S-EPMC8702856 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature