CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population.

ABSTRACT: The genetic background of Brazilians encompasses Amerindian, African, and European components as a result of the colonization of an already Amerindian inhabited region by Europeans, associated to a massive influx of Africans. Other migratory flows introduced into the Brazilian population genetic components from Asia and the Middle East. Currently, Brazil has a highly admixed population and, therefore, the study of genetic factors in the context of health or disease in Brazil is a challenging and remarkably interesting subject. This phenomenon is exemplified by the genetic variant CCR5Δ32, a 32 base-pair deletion in the CCR5 gene. CCR5Δ32 originated in Europe, but the time of origin as well as the selective pressures that allowed the maintenance of this variant and the establishment

SUBMITTER: Kulmann-Leal B 

PROVIDER: S-EPMC8703165 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature