Isolation and Identification of Inter-Species Enterovirus Recombinant Genomes.

ABSTRACT: Positive-strand RNA virus evolution is partly attributed to the process of recombination. Although common between closely genetically related viruses, such as within species of the Enterovirus genus of the Picornaviridae family, inter-species recombination is rarely observed in nature. Recent studies have shown recombination is a ubiquitous process, resulting in a wide range of recombinant genomes and progeny viruses. While not all recombinant genomes yield infectious progeny virus, their existence and continued evolution during replication have critical implications for the evolution of the virus population. In this study, we utilised an in vitro recombination assay to demonstrate inter-species recombination events between viruses from four enterovirus species, A-D. We show that inter-spe

SUBMITTER: Bentley K 

PROVIDER: S-EPMC8703282 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature