Genome-Wide Analysis of Alternative Splicing during Host-Virus Interactions in Chicken.

ABSTRACT: The chicken is a model animal for the study of evolution, immunity and development. In addition to their use as a model organism, chickens also represent an important agricultural product. Pathogen invasion has already been shown to modulate the expression of hundreds of genes, but the role of alternative splicing in avian virus infection remains unclear. We used RNA-seq data to analyze virus-induced changes in the alternative splicing of Gallus gallus, and found that a large number of alternative splicing events were induced by virus infection both in vivo and in vitro. Virus-responsive alternative splicing events preferentially occurred in genes involved in metabolism and transport. Many of the alternatively spliced transcripts were also expressed from genes with a function relating to s

SUBMITTER: Liu W 

PROVIDER: S-EPMC8703359 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature