Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake.

ABSTRACT: Past-oriented rumination and future-oriented worry are two aspects of perseverative negative thinking related to the neuroticism endophenotype and associated with depression and anxiety. Our present aim was to investigate the genomic background of these two aspects of perseverative negative thinking within separate groups of individuals with suboptimal versus optimal folate intake. We conducted a genome-wide association study in the UK Biobank database (n = 72,621) on the "rumination" and "worry" items of the Eysenck Personality Inventory Neuroticism scale in these separate groups. Optimal folate intake was related to lower worry, but unrelated to rumination. In contrast, genetic associations for worry did not implicate specific biological processes, while past-oriented rumination h

SUBMITTER: Eszlari N 

PROVIDER: S-EPMC8703428 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature