Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy.

ABSTRACT: Tissue hypoxia occurs in various conditions such as myocardial or brain ischemia and infarction, sepsis, and trauma, and induces cellular damage and tissue remodeling with recapitulation of fetal-like reprogramming, which eventually results in organ failure. Analogies seem to exist between the damaged hypoxic and developing organs, indicating that a regulatory network which drives embryonic organ development may control aspects of heart (or tissue) repair. In this context, thyroid hormone (TH), which is a critical regulator of organ maturation, physiologic angiogenesis, and mitochondrial biogenesis during fetal development, may be of important physiological relevance upon stress (hypoxia)-induced fetal reprogramming. TH signaling has been implicated in hypoxic tissue remodeling after myoca

SUBMITTER: Lourbopoulos AI 

PROVIDER: S-EPMC8703810 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature