Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles.

ABSTRACT: A series of novel S-, O- and Se-containing dispirooxindole derivatives has been synthesized using 1,3-dipolar cycloaddition reaction of azomethine ylide generated from isatines and sarcosine at the double C=C bond of 5-indolidene-2-chalcogen-imidazolones (chalcogen was oxygen, sulfur or selenium). The cytotoxicity of these dispiro derivatives was evaluated in vitro using different tumor cell lines. Several molecules have demonstrated a considerable cytotoxicity against the panel and showed good selectivity towards colorectal carcinoma HCT116 p53^+/+ over HCT116 p53^-/- cells. In particular, good results have been obtained for LNCaP prostate cell line. The performed in silico study has revealed MDM2/p53 interaction as one of the possible targets for the synthesized molec

SUBMITTER: Kukushkin M 

PROVIDER: S-EPMC8703884 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature