Controlling Water Flow through a Synthetic Nanopore with Permeable Cations.

ABSTRACT: There is presently intense interest in the development of synthetic nanopores that recapitulate the functional properties of biological water channels for a wide range of applications. To date, all known synthetic water channels have a hydrophobic lumen, and while many exhibit a comparable rate of water transport as biological water channels, there is presently no rationally designed system with the ability to regulate water transport, a critical property of many natural water channels. Here, we describe a self-assembling nanopore consisting of stacked macrocyclic molecules with a hybrid hydrophilic/hydrophobic lumen exhibiting water transport that can be regulated by alkali metal ions. Stopped-flow kinetic assays reveal a non-monotonic-dependence of transport on cation size as well as a s

SUBMITTER: Shen Y 

PROVIDER: S-EPMC8704043 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature