Genophenotypic Factors and Pharmacogenomics in Adverse Drug Reactions.

ABSTRACT: Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and illness in developed countries. ADRs show differential features depending upon genotype, age, sex, race, pathology, drug category, route of administration, and drug-drug interactions. Pharmacogenomics (PGx) provides the physician effective clues for optimizing drug efficacy and safety in major problems of health such as cardiovascular disease and associated disorders, cancer and brain disorders. Important aspects to be considered are also the impact of immunopharmacogenomics in cutaneous ADRs as well as the influence of genomic factors associated with COVID-19 and vaccination strategies. Major limitations for the routine use of PGx procedures for ADRs prevention are the lack of education and training in phy

SUBMITTER: Cacabelos R 

PROVIDER: S-EPMC8704264 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature