Set-Theoretic Formalism for Treating Ligand-Target Datasets.

ABSTRACT: Data on ligand-target (LT) interactions has played a growing role in drug research for several decades. Even though the amount of data has grown significantly in size and coverage during this period, most datasets remain difficult to analyze because of their extreme sparsity, as there is no activity data whatsoever for many LT pairs. Even within clusters of data there tends to be a lack of data completeness, making the analysis of LT datasets problematic. The current effort extends earlier works on the development of set-theoretic formalisms for treating thresholded LT datasets. Unlike many approaches that do not address pairs of unknown interaction, the current work specifically takes account of their presence in addition to that of active and inactive pairs. Because a given LT pair can b

SUBMITTER: Maggiora G 

PROVIDER: S-EPMC8704321 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature