JAK-STAT Pathway: A Novel Target to Tackle Viral Infections.

ABSTRACT: Modulation of the antiviral innate immune response has been proposed as a putative cellular target for the development of novel pan-viral therapeutic strategies. The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is especially relevant due to its essential role in the regulation of local and systemic inflammation in response to viral infections, being, therefore, a putative therapeutic target. Here, we review the extraordinary diversity of strategies that viruses have evolved to interfere with JAK-STAT signaling, stressing the relevance of this pathway as a putative antiviral target. Moreover, due to the recent remarkable progress on the development of novel JAK inhibitors (JAKi), the current knowledge on its efficacy against distinct viral infections is a

SUBMITTER: Ezeonwumelu IJ 

PROVIDER: S-EPMC8704679 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature