Rutin-Loaded Nanovesicles for Improved Stability and Enhanced Topical Efficacy of Natural Compound.

ABSTRACT: Rutin is a natural compound with several pharmacological effects. Among these, antioxidant activity is one of the best known. Despite its numerous benefits, its topical application is severely limited by its physicochemical properties. For this reason, the use of suitable systems could be necessary to improve its delivery through skin, thus enhancing its pharmacological effects. In this regard, the aim of this work is to optimize the ethosomal dispersion modifying both lipid and ethanol concentrations and encapsulating different amounts of rutin. Characterization studies performed on the realized systems highlighted their great stability properties. Studies of encapsulation efficiency and loading degree allowed us to identify a better formulation (EE% 67.5 ± 5.2%, DL% 27 ± 1.7%), which was

SUBMITTER: Cristiano MC 

PROVIDER: S-EPMC8704772 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature